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by Katie Crum, Fairleigh Dickinson University

One-hundred and forty people were accused of witchcraft. See the  page for a list of the accused.

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The witchcraft outbreak originated in Salem Village with Betty Parris being the first afflicted girl. See the essay for a detailed explanation of the causes and events of the Salem witch trials.

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Except in one respect: doctors had no more clarity after the trial about how to treat brain cancer patients than they had before. Some patients did do better on the drug, and indeed, doctors and patients insist that some who take Avastin significantly beat the average. But the trial was unable to discover these “responders” along the way, much less examine what might have accounted for the difference. (Dr. Gilbert is working to figure that out now.)

Forty-three people were afflicted. See the  page for a list of the afflicted.

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So what’s the solution? For subtypes of disease that are already known, it may be feasible to design small clinical trials and enroll only those who have the appropriate genetic or molecular signature. That’s what Genentech did in developing the drug Herceptin, which homes in on tumor cells that have an abundance of a protein called HER2.

“What he was saying,” marvels Dr. Berry, “was, ‘We’re playing the lottery.’ ”

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Overview Essays – Women Film Pioneers Exhibiting Women: Gender, Showmanship, and the Professionalization of Film Exhibition in the United States, 1900–1930O Pioneers Essays | GradeSaverO Pioneers literature essays are academic essays for citation These papers were written primarily by students and provide critical analysis of O PioneersO Pioneers, Willa Cather - Essay - Essays and criticism on Willa Cather s O Pioneers! - O Pioneers, Willa Cather

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But at the annual meeting of the American Society of Clinical Oncology last month, much of the buzz surrounded a study that was anything but a breakthrough. To a packed and whisper-quiet room at the McCormick Place convention center in , Mark R. Gilbert, a professor of neuro-oncology at the M. D. Anderson Cancer Center in , presented the results of a clinical trial testing the drug in patients newly diagnosed with glioblastoma multiforme, an aggressive brain cancer. In two earlier, smaller studies of patients with recurrent brain cancers, tumors shrank and the disease seemed to stall for several months when patients were given the drug, an antibody that targets the blood supply of these fast-growing masses of cancer cells.

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The Rev. Samuel Parris had a relatively small family. He was married and had a nine yearold daughter, Betty, and a twelve year old niece, Abigail Williams, who was an orphan. Abigail was expected to earn her keep by doing most of the household chores, and alsocare for her invalid aunt. Betty’s poor health prevented her from helping with thehousehold chores, so much of the work feel on Abigail’s young shoulders.